The healing power of psychedelics

Science is one step closer to reverse the damage of chronic stress

Joy Ride

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Stress is inevitable and suffering is universal, but victimhood is optional. The choice is yours, says Dr.Eger, who survived a concentration camp during World War II and reflected on life in her book. However, it is not easy to change the brain by using the brain itself. Stress causes maladaptive plasticity within the brain’s reward circuit. The mood and anxiety disorders affect one out of every six people in their lifetime and cost the United States economy an excess of $50 billion per year.

The recent good news stemmed from new studies attempting to tune the brain’s plasticity back to normal and undoing the damaging effects of a stressful life. By undoing the harm of the stress on brain signaling and functioning, the symptoms of anhedonia (inability to feel pleasure) and social avoidance (prevalent in depressed individuals) may resolve.

Learning from animal studies

First, to understand and measure chronic stress, scientists introduced an animal model of social defeat stress. The protocol is simple, and it takes 3–4 weeks and a couple of mice to complete. You need at least two mice — one is repeatedly subjected to bouts of social defeat by a larger aggressive mouse. After a while, the first mouse tries to avoid the second one. And if the test is repeated, the stressed mouse will develop a depression-like phenotype marked by anhedonia, anxiety, and social-avoidance behaviors.

Stress induces synaptic plasticity within several different brain regions is causally linked to depression-like behaviors in animals. That means that the brain is altered by chronic stress. Neurobiological changes underlying mood and anxiety disorders are directly related to different brain areas like the hippocampus and prefrontal cortex. Compared to a stress-free mouse, in a chronically stressed mouse, the expression of presynaptic proteins and structural neuroplasticity was significantly altered.

The next step is to figure out if the altered state could be dialed back to normal. And the study with pigs may have provided some additional clues to that. According to a fascinating recent publication, brain alterations induced by stress appear…

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Joy Ride

Learner, writer, biotech investor, research translation, drug development, genetics. 4-lingual.